Efficient Microwave-Assisted Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions in 5-Nitroimidazole Series

Abstract

A new simple, rapid and high yielding synthesis (mean yield = 83%) of various 4-aryl, 4-heteroaryl, and 4-styryl-1,2-di­methyl-5-nitro-1H-imidazoles by palladium-catalyzed Suzuki-Miyaura cross-coupling reactions using microwave irradiation is described.

cross-coupling - 5-nitroimidazoles - palladium - Suzuki reaction - arylations

References

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Detailed X-ray crystallographic data are available from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2, 1EZ, UK; fax: [phone]; email: [e-mail]. (compound 20: CCDC # 704224 and compound 21: CCDC # 716232). These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.